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Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
Gene Name: | protein phosphatase 1, regulatory subunit 15A |
Synonyms: | PPP1R15A, GADD34 |
Target Sequences: | NM_014330 NP_055145.3 O75807 |
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