Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
Gene Name: | protein phosphatase, Mg2+/Mn2+ dependent, 1F |
Family/Subfamily: | Protein Phosphatase , PP2C |
Synonyms: | PPM1F, CAMKP, CaMKPase, FEM-2, PP2C phosphatase, Protein fem-2 homolog, Protein phosphatase 1F, POPX2, CaM-kinase phosphatase, HFEM-2, KIAA0015, Partner of PIX 2 |
Target Sequences: | NM_014634 NP_055449.1 P49593 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.