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Newark, CA 94560
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PPIP5K2 / HISPPD1
diphosphoinositol pentakisphosphate kinase 2
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.
| Gene Name: | diphosphoinositol pentakisphosphate kinase 2 |
| Synonyms: | PPIP5K2, HsVIP2, IP7K2, InsP6 and PP-IP5 kinase 2, KIAA0433, HISPPD1, VIP1 homolog 2, Vip2 |
| Target Sequences: | NM_015216 NP_056031.2 O43314 |
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