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PPIB / Cyclophilin B is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.
Gene Name: | peptidylprolyl isomerase B (cyclophilin B) |
Synonyms: | PPIB, Cyclophilin B, CYP-S1, S-cyclophilin, Rotamase B, Cyclophilin-like protein, CYPB, OI9, PPIase B, SCYLP |
Target Sequences: | NM_000942 NP_000933.1 P23284 |
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