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The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region.
Gene Name: | phosphoribosyl pyrophosphate amidotransferase |
Synonyms: | PPAT, Amidophosphoribosyltransferase, ATASE, GPAT, PRAT |
Target Sequences: | NM_002703 NP_002694.3 Q06203 |
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