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PPARD / PPAR Delta

peroxisome proliferator-activated receptor delta

PPARD / PPAR Delta is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.

Gene Name: peroxisome proliferator-activated receptor delta
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: PPARD, FAAR, NUCI, PPAR-beta, PPAR-delta, NR1C2, NUC1, NUCII, Nuclear hormone receptor 1, PPARB, PPAR Delta
Target Sequences: NM_006238 NP_006229.1 Q03181

Publications (2)

1
Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus. Chen H, Li J, Li H, Hu Y, Tevebaugh W, Yamamoto M, Que J, Chen X. PloS one. 2012 7:e36504. (IHC-P; Mouse) [Full Text Article] [PubMed:22567161] [PMC:PMC3342176] Related Antibodies: LS-B45.
2
The PPARd Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos. Muhammad Idrees, Lianguang Xu, Marwa El Sheikh, Tabinda Sidrat, Seok-Hwan Song, Myeong-Don Joo, Kyeong-Lim Lee, Il-Keun Kong. International journal of molecular sciences. 2019 Dec;20:6066. [Full Text Article] [PubMed:31810173] [PMC:PMC6928732] Related Antibodies: LS-C437498.

☰ Filters
Products
Proteins (14)
Over-Expression Lysate (8)
Recombinant (6)
PPARD / PPAR Delta (14)
No (14)
GST (1)
GST, N-terminus (1)
His (2)
His, N-Terminal (1)
Myc-DDK (Flag) (9)
Human (8)
Mouse (2)
293T Cells (4)
E. coli (3)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Purified (1)
PPARD / PPAR Delta Protein - Recombinant Peroxisome Proliferator Activated Receptor Delta By SDS-PAGE
Select
E. coli
His, N-Terminal
20.1 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
PPARD / PPAR Delta Protein - 12.5% SDS-PAGE of human PPARD stained with Coomassie Blue
Select
Wheat Germ Extract
GST
65.45 kDa
2 µg/$439
PPARD / PPAR Delta Protein - Purified recombinant protein PPARD was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
49.7 kDa
20 µg/$1,107
PPARD / PPAR Delta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
50.4 kDa
20 µg/$150
PPARD / PPAR Delta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
46.2 kDa
20 µg/$150
PPARD / PPAR Delta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
39.3 kDa
20 µg/$150
PPARD / PPAR Delta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
49.7 kDa
20 µg/$215
PPARD / PPAR Delta Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PPARD / PPAR Delta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
39.3 kDa
100 µg/$494
PPARD / PPAR Delta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
46.2 kDa
100 µg/$494
PPARD / PPAR Delta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
50.4 kDa
100 µg/$494
PPARD / PPAR Delta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
49.7 kDa
100 µg/$710
PPARD / PPAR Delta Protein - Recombinant Peroxisome Proliferator Activated Receptor Delta By SDS-PAGE
Select
E. coli
His
20.2 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
PPARD / PPAR Delta Protein
Select
E. coli
His
14.4 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Viewing 1-14 of 14 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).