Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
Gene Name: | peroxisome proliferator-activated receptor alpha |
Family/Subfamily: | NHR , NR1 Thyroid hormone-like |
Synonyms: | PPARA, PPAR Alpha, PPARalpha, PPAR-alpha, NR1C1, HPPAR, PPAR |
Target Sequences: | NM_005036 NP_005027.2 Q07869 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.