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PPARA / PPAR Alpha

peroxisome proliferator-activated receptor alpha

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.

Gene Name: peroxisome proliferator-activated receptor alpha
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: PPARA, PPAR Alpha, PPARalpha, PPAR-alpha, NR1C1, HPPAR, PPAR
Target Sequences: NM_005036 NP_005027.2 Q07869

Publications (1)

1
PIM1 drives lipid droplet accumulation to promote proliferation and survival in prostate cancer. Shailender S Chauhan, Andrea L Casillas, Andres D Vizzerra, Hope Liou, Amber N Clements, Caitlyn E Flores, Christopher T Prevost, David F Kashatus, Ashley J Snider, Justin M Snider, Noel A Warfel. Oncogene. 2024 February;43:406-419. [Full Text Article] [PubMed:38097734] [PMC:PMC10837079] Related Antibodies: LS-B46.

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Antibodies (83)
Primary (83)
PPARA / PPAR Alpha (83)
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monoclonal mc (20)
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1331CT894.186.143 (1)
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PPARA / PPAR Alpha Antibody - Anti-PPAR Alpha antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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PPARA / PPAR Alpha Rabbit anti-Mouse Polyclonal (aa1-25) Antibody
Mouse, Dog, Bovine, Rat, Hamster-Golden Syrian, Boar
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$515
PPARA / PPAR Alpha Antibody - Anti-PPAR Alpha antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PPARA / PPAR Alpha Rabbit anti-Human Polyclonal (aa22-36) Antibody
Mouse, Dog, Rat, Hamster, Human, Monkey
IHC-P, WB
Unconjugated
1 Each/$485
PPARA / PPAR Alpha Antibody - Immunohistochemical of paraffin-embedded H. skeletal muscle section using PPARA Antibody. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (1331CT894.186.143) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PPARA / PPAR Alpha Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PPARA / PPAR Alpha Rabbit anti-Human Polyclonal (aa153-181) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PPARA / PPAR Alpha Antibody - PPARA / PPAR antibody Western blot of OVCAR-3 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PPARA / PPAR Alpha Rabbit anti-Human Polyclonal (aa51-100) Antibody
Human
WB
Unconjugated
100 µl/$424
PPARA / PPAR Alpha Antibody - Immunofluorescence of monoclonal antibody to PPARA on HeLa cell . [antibody concentration 10 ug/ml]
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (1A8) Antibody
Human
ELISA, IF
Unconjugated
100 µg/$423
PPARA / PPAR Alpha Antibody - Immunohistochemistry using the anti-PPAR antibody, showing staining of PPAR alpha in rat brain sections, highlighting cytoplasmic staining in ependymal cells and neurons in frontal cortex. Bottom image shows subventricular zone (svz) of lateral ventrical (exit point of progenitor olfactory neurones); top image shows frontal cortex in the same section. Cytoplasmic staining is also observed in the corpus callosum (bottom image) and in dendritic fields of the cortex. Formalin/PFA-fixed paraffin-embedded sections of rat brain tissue were incubated with the primary antibody at 1:200 for 1 hour. Antigen retrieval was performed by heat induction in citrate buffer pH 6.0.
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PPARA / PPAR Alpha Rabbit anti-Mouse Polyclonal (aa1-25) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
Unconjugated
25 µl/$304
PPARA / PPAR Alpha Antibody - Western blot of PPAR-alpha antibody
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PPARA / PPAR Alpha Rabbit anti-Human Polyclonal (1-80 aa) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (5D10C3) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (5D10E10) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
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PPARA / PPAR Alpha Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$448
PPARA / PPAR Alpha Antibody - IHC of paraffin-embedded Human prostate tissue using anti-PPARA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (aa145-420) (OTI2G6) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PPARA / PPAR Alpha Antibody - IHC of paraffin-embedded Human prostate tissue using anti-PPARA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (aa145-420) (Carrier-free) (OTI2G6) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PPARA / PPAR Alpha Antibody - 1:100 staining mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PPARA / PPAR Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PPARA / PPAR Alpha Antibody - PPARA / PPAR antibody Western blot of Rat Brain lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PPARA / PPAR Alpha Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat, Human
WB
Unconjugated
100 µl/$424
PPARA / PPAR Alpha Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PPARA / PPAR Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PPARA / PPAR Alpha Antibody - Anti-PPARA mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPARA.
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (OTI2F3) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
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PPARA / PPAR Alpha Rabbit anti-Mouse Polyclonal (aa1-18) Antibody
Mouse, Human, Monkey
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$832
PPARA / PPAR Alpha Antibody - Anti-PPARA mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPARA.
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (OTI3G3) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
PPARA / PPAR Alpha Antibody - Anti-PPARA mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPARA.
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (aa145-420) (Carrier-free) (OTI3G3) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
PPARA / PPAR Alpha Antibody - Anti-PPARA mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPARA.
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (OTI2E7) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
PPARA / PPAR Alpha Antibody - Anti-PPARA mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPARA.
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (aa145-420) (Carrier-free) (OTI2E7) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
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PPARA / PPAR Alpha Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
PPARA / PPAR Alpha Antibody - Anti-PPARA mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPARA.
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (aa145-420) (OTI2D10) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
PPARA / PPAR Alpha Antibody - Anti-PPARA mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPARA.
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PPARA / PPAR Alpha Mouse anti-Human Monoclonal (aa145-420) (Carrier-free) (OTI2D10) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).