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Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.
Gene Name: | POU class 2 associating factor 1 |
Synonyms: | POU2AF1, BOB-1, OBF-1, OCT-binding factor 1, BOB1, OBF1, OCA-B, OCAB |
Target Sequences: | NM_006235 NP_006226.2 Q16633 |
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