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PON3 is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.
Gene Name: | paraoxonase 3 |
Synonyms: | PON3, Paraoxonase 3, Paraoxanase-3, Serum paraoxonase/lactonase 3 |
Target Sequences: | L48516 AAC41996.1 Q15166 |
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