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O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that tranfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.
Gene Name: | protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) |
Synonyms: | POMGNT2, AGO61, EOGTL, MDDGA8, GTDC2, C3orf39 |
Target Sequences: | NM_032806 NP_116195.2 Q8NAT1 |
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