POMC / Proopiomelanocortin

proopiomelanocortin

POMC / Proopiomelanocortin is a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

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Products

Antibodies (79)

ELISA Kits (35)

Proteins (10)

Type

Competitive EIA (15)

Custom (4)

Over-Expression Lysate (3)

Primary (79)

Recombinant (6)

Sandwich (14)

Sandwich CLIA (2)

Synthetic Peptide (1)

Target

POMC / Proopiomelanocortin (124)

Reactivity

Human (67)

Mouse (23)

Rat (20)

Chicken (2)

Guinea pig (2)

Monkey (3)

Pig (2)

Porcine (2)

Rabbit (2)

Sheep (1)

Application

IHC (12)

IHC-P (11)

WB (61)

DB (1)

ELISA (29)

IF (2)

IHC-Fx (2)

Peptide-ELISA (2)

SDS-PAGE (2)

Host

rabbit (59)

mouse (19)

goat (1)

Product Group

IHCPlus (3)

PathPlus Cancer (1)

PathPlus Cancer Pathology (1)

Isotype

IgG (30)

IgG1 (11)

IgG1,k (4)

IgG2a (3)

Clonality

monoclonal mc (15)

polyclonal pc (58)

recombinant monoclonal rmc (6)

Clone

3E11 (1)

5D3A10 (1)

6D2B5 (1)

CLIP/2040R (2)

OTI1A8 (2)

OTI1B9 (2)

OTI1F3 (2)

OTI2B2 (2)

OTI4G4 (2)

r57 (2)

rCLIP/1407 (2)

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Format

12 x 8-Well Microstrips (2)

96-Well Microplate (3)

96-Well Strip Plate (30)

APC (3)

APC Conjugated (3)

Azide-free (3)

Biotin Conjugated (11)

Carrier-free (8)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (3)

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Rhodamine Conjugated (1)

Unconjugated (49)

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Epitope

aa27-235 (16)

aa23-267 (8)

N-Terminus (2)

aa1-24 (2)

aa25-39 (2)

aa138-176 (1)

aa256-267 (1)

aa27-52 (1)

pSer168 (1)

Publications

No (124)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (2)

Plasma (19)

Serum (20)

Tissue Homogenates (2)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Synthetic (1)

Wheat Germ Extract (2)

Purification

Purified (4)

Select

POMC / Proopiomelanocortin Antibody (clone OTI2B2) LS-C340619

Antibody:

POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (OTI2B2) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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POMC / Proopiomelanocortin Antibody (clone OTI2B2, Carrier-free) LS-C788242

Antibody:

POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (Carrier-free) (OTI2B2) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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POMC / Proopiomelanocortin Antibody (Preservative Free) LS-C149261

Antibody:

POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452

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POMC / Proopiomelanocortin Antibody (Preservative Free, Biotin) LS-C343585

Antibody:

POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal (Preservative Free) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated, Preservative Free

Price:

50 µg/$343

• Unconjugated, Preservative Free
• Biotin, Preservative Free

• Unconjugated, Preservative Free
• Biotin, Preservative Free

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Rat POMC / Proopiomelanocortin (Competitive EIA) ELISA Kit - LS-F8723

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

123.5 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$750

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POMC / Proopiomelanocortin Antibody LS-C332332

Antibody:

POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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Human POMC / Proopiomelanocortin (Competitive EIA) ELISA Kit - LS-F11172

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse POMC / Proopiomelanocortin (Sandwich ELISA) ELISA Kit - LS-F22478

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.39 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human POMC / Proopiomelanocortin Protein (Recombinant His) - LS-G1310

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Rat POMC / Proopiomelanocortin (Competitive EIA) ELISA Kit - LS-F28047

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

5 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

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Human POMC / Proopiomelanocortin Protein (Over-Expression Lysate 6His, N-terminus) (Pro2-Glu267) - LS-G26682

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

29 kDa

Price:

100 µg/$298

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Mouse POMC / Proopiomelanocortin Protein (Recombinant His-T7) (aa27-235) - LS-G13636

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.0 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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POMC / Proopiomelanocortin Antibody LS-C402460

Antibody:

POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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POMC / Proopiomelanocortin Antibody (aa27-235) LS-C372704

Antibody:

POMC / Proopiomelanocortin Rabbit anti-Mouse Polyclonal (aa27-235) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

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POMC / Proopiomelanocortin Antibody (aa27-235, Biotin) LS-C685718

Antibody:

POMC / Proopiomelanocortin Rabbit anti-Mouse Polyclonal (aa27-235) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317

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POMC / Proopiomelanocortin Antibody (aa27-235, FITC) LS-C692240

Antibody:

POMC / Proopiomelanocortin Rabbit anti-Mouse Polyclonal (aa27-235) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$345; 200 µl/$402; 500 µl/$594; 1 ml/$737; 2 ml/$976; 5 ml/$1,676

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POMC / Proopiomelanocortin Antibody (aa27-235, Cy3) LS-C700398

Antibody:

POMC / Proopiomelanocortin Rabbit anti-Mouse Polyclonal (aa27-235) (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395

• Unconjugated
• Biotin
• FITC
• Cy3

• Unconjugated
• Biotin
• FITC
• More...
  • Cy3

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Mouse POMC / Proopiomelanocortin (Sandwich ELISA) ELISA Kit - LS-F28933

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

50 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Human POMC / Proopiomelanocortin (Sandwich ELISA) ELISA Kit - LS-F32862

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Serum

Price:

1 Plate/$579

Select

POMC / Proopiomelanocortin Antibody (clone OTI1A8, Carrier-free) LS-C788239

Antibody:

POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (Carrier-free) (OTI1A8) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

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POMC / Proopiomelanocortin Protein (Synthetic Peptide) - LS-G37549

Source:

Synthetic

Tag:

None

Molecular Weight:

1665 Da

Price:

0.5 mg/$293

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POMC / Proopiomelanocortin Antibody LS-C405729

Antibody:

POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

POMC / Proopiomelanocortin Antibody (clone 6D2B5) LS-C669497

Antibody:

POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (6D2B5) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µl/$459

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POMC / Proopiomelanocortin Antibody LS-C832594

Antibody:

POMC / Proopiomelanocortin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

POMC / Proopiomelanocortin Antibody (clone OTI1F3) LS-C338137

Antibody:

POMC / Proopiomelanocortin Mouse anti-Human Monoclonal (OTI1F3) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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