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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
Gene Name: | polymerase (RNA) I polypeptide B, 128kDa |
Synonyms: | POLR1B, RNA polymerase I subunit 2, RPA135, Rpo1-2 |
Target Sequences: | NM_019014 NP_061887.2 Q9H9Y6 |
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