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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
Gene Name: | polymerase (RNA) I polypeptide A, 194kDa |
Synonyms: | POLR1A, A190, DKFZP586M0122, RPO14, RNA polymerase I subunit A1, RPA194, RPO1-4 |
Target Sequences: | NM_015425 NP_056240.2 O95602 |
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