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Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Gene Name: | polymerase (DNA directed) iota |
Synonyms: | POLI, DNA polymerase iota, Eta2, Polymerase (DNA directed) iota, RAD30 homolog B, RAD3OB, RAD30B |
Target Sequences: | NM_007195 NP_009126.2 Q9UNA4 |
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