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POLD2 is the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.
Gene Name: | polymerase (DNA directed), delta 2, accessory subunit |
Synonyms: | POLD2, DNA polymerase delta subunit 2, Pol delta B subunit (p50), DNA polymerase delta p50 |
Target Sequences: | NM_006230 NP_006221.2 P49005 |
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