Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13.
Gene Name: | protein O-fucosyltransferase 2 |
Synonyms: | POFUT2, C21orf80, KIAA0958, FUT13, Protein O-fucosyltransferase 2, O-FucT-2, Peptide-O-fucosyltransferase 2 |
Target Sequences: | NM_015227 NP_056042.1 Q9Y2G5 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.