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PMP22

peripheral myelin protein 22

PMP22 is a major component of myelin expressed in the compact portion of essentially all myelinated fibers in the peripheral nervous system and is produced predominantly by Schwann cells. Studies in injured nerve suggested a role during Schwann cell growth and differentiation. PMP22 is expressed in cranial nerves but not in the mature central nervous system. Studies suggest a possible role of the PMP22 gene in the development of neoplasia in patients with neurofibromatosis and in the myelin degenerative Charcot-Marie-Tooth disease linked to chromosome 17p.

Gene Name: peripheral myelin protein 22
Synonyms: PMP22, CMT1E, DSS, GAS-3, GAS3, Growth arrest-specific 3, HMSNIA, PMP-22, CMT1A, HNPP, Peripheral myelin protein 22
Target Sequences: NM_000304 NP_000295.1 Q01453

Publications (2)

1
Characterization of a monoclonal antibody specific for human peripheral myelin protein 22 and its use in immunohistochemical studies of the fetal and adult nervous system. Gregson NA, Zhang G, Pritchard J, Wang A, Sanvito L, Hayday AC, Hughes RA. Journal of the peripheral nervous system : JPNS. 2007 12:10-Feb. (IHC) [PubMed:17374097]
2
Pmp22 super-enhancer deletion causes tomacula formation and conduction block in peripheral nerves. Harrison Pantera, Bo Hu, Daniel Moiseev, Chris Dunham, Jibraan Rashid, John J Moran, Kathleen Krentz, C Dustin Rubinstein, Seongsik Won, Jun Li, John Svaren. Human molecular genetics. 2020 June;29:1689-1699. [Full Text Article] [PubMed:32356557] [PMC:PMC7322568] Related Antibodies: LS-C383645.

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Products
Antibodies (48)
Primary (48)
PMP22 (48)
Human (48)
Mouse (5)
Rat (4)
Bovine (4)
Chimpanzee (3)
Gibbon (3)
Guinea pig (3)
Monkey (5)
Orangutan (3)
Rabbit (3)
IHC (14)
IHC-P (5)
WB (37)
ELISA (20)
IF (1)
IP (1)
Peptide-ELISA (1)
rabbit (35)
mouse (13)
IgG (20)
IgG1 (4)
IgG2a,k (8)
IgG2b,k (1)
monoclonal mc (13)
polyclonal pc (35)
3G10 (1)
C10 (8)
CF1 (2)
OTI5D1 (2)
AP Conjugated (1)
APC (2)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (6)
Carrier-free (1)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (4)
Unconjugated (17)
aa1-160 (8)
aa102-130 (7)
aa27-76 (4)
80-160 aa, C-terminal (1)
Ala142 (1)
C-Terminus (1)
Extracellular Domain (1)
aa121-133 (1)
No (47)
Yes (1)
PMP22 Antibody - Western blot of GAS3 antibody
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PMP22 Rabbit anti-Human Polyclonal (80-160 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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PMP22 Mouse anti-Human Monoclonal (aa121-133) (CF1) Antibody
Human, Monkey
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$826
PMP22 Antibody - Immunohistochemical analysis of GAS3 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PMP22 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351
PMP22 Antibody - PMP22 staining in human paraffin embedded formalin fixed nerve section. Peripheral nerve myelin sheats are stained with monoclonal antibody CF1
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PMP22 Mouse anti-Human Monoclonal (Extracellular Domain) (CF1) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µg/$554
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PMP22 Rabbit anti-Human Polyclonal (Ala142) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
PMP22 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-PMP22 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:2000)
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PMP22 Mouse anti-Human Monoclonal (OTI5D1) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
PMP22 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-PMP22 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:2000)
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PMP22 Mouse anti-Human Monoclonal (Carrier-free) (OTI5D1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PMP22 Antibody - Staining MDA-MB-435 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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PMP22 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PMP22 Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human brain tissue using PMP22 antibody.
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PMP22 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
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PMP22 Rabbit anti-Human Polyclonal (aa102-130) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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PMP22 Rabbit anti-Human Polyclonal (aa102-130) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
PMP22 Rabbit anti-Human Polyclonal (aa102-130) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
PMP22 Rabbit anti-Human Polyclonal (aa102-130) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
PMP22 Rabbit anti-Human Polyclonal (aa102-130) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
PMP22 Rabbit anti-Human Polyclonal (aa102-130) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
PMP22 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC
HRP Conjugated
100 µl/$632
Select
PMP22 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC
Biotin Conjugated
100 µl/$632
Select
PMP22 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC
FITC Conjugated
100 µl/$632
Select
PMP22 Rabbit anti-Human Polyclonal (PE) Antibody
Human
ELISA, IHC
PE Conjugated
100 µl/$632
Select
PMP22 Rabbit anti-Human Polyclonal (AP) Antibody
Human
ELISA, IHC
AP Conjugated
100 µl/$632
Select
PMP22 Rabbit anti-Human Polyclonal (APC) Antibody
Human
ELISA, IHC
APC Conjugated
100 µl/$632
PMP22 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PMP22 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P, WB
Unconjugated
20 µl/$275; 100 µl/$389
Select
PMP22 Mouse anti-Human Monoclonal (3G10) Antibody
Human
ELISA
Unconjugated
100 µg/$423
PMP22 Antibody - Western Blot; Sample: Recombinant PMP22, Human.
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PMP22 Mouse anti-Human Monoclonal (C10) Antibody
Human
WB
Unconjugated
100 µl/$314; 200 µl/$359; 500 µl/$507; 1 ml/$581
PMP22 Antibody - Immunofluorescent analysis of HepG2 cells using PMP22 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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PMP22 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
Viewing 1-25 of 48 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).