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PLN / Phospholamban

phospholamban

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

Gene Name: phospholamban
Synonyms: PLN, CMD1P, CMH18, PLB, Cardiac phospholamban, Phospholamban
Target Sequences: NM_002667 NP_002658.1 P26678

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
PLN / Phospholamban (5)
No (5)
GST (1)
GST, N-terminus (1)
His-GST (1)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Yeast (1)
PLN / Phospholamban Protein
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Yeast
GST
33.51 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
PLN / Phospholamban Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PLN / Phospholamban Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
6.6 kDa
100 µg/$494
PLN / Phospholamban Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
6.6 kDa
20 µg/$150
PLN / Phospholamban Protein - Recombinant Phospholamban By SDS-PAGE
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E. coli
His-GST
38.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).