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PLD3 / Phospholipase D3 is a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Gene Name: | phospholipase D family, member 3 |
Synonyms: | PLD3, HindIII K4L homolog, HU-K4, HuK4, PLD 3, Choline phosphatase 3, Phospholipase D3 |
Target Sequences: | NM_012268 NP_036400.2 Q8IV08 |
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