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PLCG2 / PLC Gamma 2

phospholipase C, gamma 2 (phosphatidylinositol-specific)

PLCG2 / PLC Gamma 2 is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.

Gene Name: phospholipase C, gamma 2 (phosphatidylinositol-specific)
Family/Subfamily: Phospholipase , not assigned-Phospholipase
Synonyms: PLCG2, FCAS3, Phospholipase C-gamma-2, PLCG 2, PLC-IV, APLAID, Phospholipase C-IV, PLC-gamma-2
Target Sequences: NM_002661 NP_002652.2 P16885

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Products
Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
PLCG2 / PLC Gamma 2 (5)
No (5)
His (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Low endotoxin level (1)
PLCG2 / PLC Gamma 2 Protein - Purified recombinant protein PLCG2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
147.7 kDa
20 µg/$1,107
PLCG2 / PLC Gamma 2 Protein - Recombinant Phospholipase C Gamma 2, Phosphatidylinositol Specific By SDS-PAGE
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E. coli
His-T7
29.3 kDa
10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142
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293T Cells
Myc-DDK (Flag)
147.7 kDa
20 µg/$150
PLCG2 / PLC Gamma 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
147.7 kDa
100 µg/$494
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E. coli
200 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
22.11 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).