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Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.
Gene Name: | Phospholipase C, Delta 3 |
Synonyms: | PLCD3, PLC-delta-3, KIAA1964, Phospholipase C, delta 3, Phospholipase C-delta-3, PLC delta3 |
Target Sequences: | Q8N3E9 Q8N3E9 |
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