PLAU / Urokinase / uPA

plasminogen activator, urokinase

PLAU / Urokinase / uPA is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Products

Proteins (14)

Type

Over-Expression Lysate (2)

Recombinant (12)

Target

PLAU / Urokinase / uPA (14)

Publications

No (14)

Tag

6His, C-terminus (2)

6His, N-terminus (1)

GST, N-terminus (1)

His (4)

His, N-Terminal (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (10)

Mouse (1)

Pig (1)

Rat (1)

Source

293T Cells (1)

E. coli (6)

HEK 293 Cells (2)

Human Cells (3)

Mammalian Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (5)

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Mouse PLAU / Urokinase / uPA Protein (Recombinant His, N-Terminal) (aa180-433) - LS-G11665

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

31.9 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209

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Human PLAU / Urokinase / uPA Protein (Recombinant 6His, C-terminus) (Ser21-Leu431) - LS-G38913

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.41kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Human PLAU / Urokinase / uPA Protein (Recombinant GST, N-terminus) (aa16-115) - LS-G59631

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PLAU / Urokinase / uPA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99826

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.51 kDa

Price:

100 µg/$494

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Human PLAU / Urokinase / uPA Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67302

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.3 kDa

Price:

20 µg/$1,107

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Human PLAU / Urokinase / uPA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79507

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.51 kDa

Price:

20 µg/$150

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Human PLAU / Urokinase / uPA Protein (Recombinant 6His, C-terminus) (Ser21-Leu431) - LS-G140511

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.4 kDa

Price:

10 µg/$344; 50 µg/$584

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Human PLAU / Urokinase / uPA Protein (Recombinant His) (aa21-177) - LS-G141078

Source:

E. coli

Sequence Length:

156 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

17.27 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Rat PLAU / Urokinase / uPA Protein (Recombinant His-T7) (aa17-432) - LS-G23931

Source:

E. coli

Tag:

His-T7

Molecular Weight:

49.7 kDa

Price:

10 µg/$287; 50 µg/$477; 100 µg/$762; 200 µg/$952; 1 mg/$2,083; 500 µg/$1,613; 5 mg/$3,333; 2 mg/$2,272

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Human PLAU / Urokinase / uPA Protein (Recombinant 6His, N-terminus) (Ser21-Leu431) - LS-G26393

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

46 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human PLAU / Urokinase / uPA Protein (Recombinant His) (aa21-173) - LS-G22629

Source:

E. coli

Tag:

His

Molecular Weight:

21.4 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human PLAU / Urokinase / uPA Protein (Recombinant His) (Met1-Leu431) - LS-G98639

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46 kDa

Price:

50 µg/$997

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Human PLAU / Urokinase / uPA Protein (Recombinant His) (Met1-Leu431) - LS-G98641

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46 kDa

Price:

20 µg/$502

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Pig PLAU / Urokinase / uPA Protein (Recombinant His-T7) (aa21-168) - LS-G11666

Source:

E. coli

Tag:

His-T7

Molecular Weight:

20.3 kDa

Price:

10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383

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