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PLAT / TPA is tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Gene Name: | plasminogen activator, tissue |
Family/Subfamily: | Protease , Serine S1 |
Synonyms: | PLAT, Plasminogen activator, Plasminogen activator, tissue, Tissue plasminogen activator, T-PA, T-plasminogen activator, TPA |
Target Sequences: | NM_000930 NP_000921.1 P00750 |
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