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PLA2R / PLA2R1

phospholipase A2 receptor 1, 180kDa

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

Gene Name: phospholipase A2 receptor 1, 180kDa
Family/Subfamily: Phospholipase , not assigned-Phospholipase
Synonyms: PLA2R1, CLEC13C, M-type receptor, PLA2IR, PLA2-R, PLA2G1R, PLA2R
Target Sequences: NM_007366 NP_031392.3 Q13018

Publications (1)

1
A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier. Petrosyan A, Cravedi P, Villani V, Angeletti A, Manrique J, Renieri A, De Filippo RE, Perin L, Da Sacco S. Nature communications. 2019 August;10:3656. [Full Text Article] [PubMed:31409793] [PMC:PMC6692336] Related Antibodies: LS-C153547.

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Products
Antibodies (27)
Primary (27)
PLA2R / PLA2R1 (27)
Human (19)
Mouse (10)
Rat (2)
Monkey (1)
IHC (2)
WB (22)
Flo (1)
ELISA (6)
Peptide-ELISA (1)
rabbit (26)
goat (1)
IgG (7)
polyclonal pc (27)
APC (2)
APC Conjugated (2)
Biotin Conjugated (3)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (10)
aa1418-1487 (8)
aa385-643 (8)
aa395-530 (4)
C-Terminus (2)
aa946-957 (1)
No (26)
Yes (1)
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PLA2R / PLA2R1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$440; 100 µg/$480
PLA2R / PLA2R1 Antibody - PLA2R1 antibody (1 ug/ml) staining of Human Ileum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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PLA2R / PLA2R1 Goat anti-Human Polyclonal (aa946-957) Antibody
Human, Monkey
Flo, Peptide-ELISA
Unconjugated
100 µg/$503
PLA2R / PLA2R1 Antibody - Western blot of PLA2R / PLA2R1 antibody.
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PLA2R / PLA2R1 Rabbit anti-Mouse Polyclonal (aa1418-1487) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
PLA2R / PLA2R1 Antibody - Western blot of PLA2R / PLA2R1 antibody.
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PLA2R / PLA2R1 Rabbit anti-Mouse Polyclonal (aa1418-1487) (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
PLA2R / PLA2R1 Antibody - Western blot of PLA2R / PLA2R1 antibody.
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PLA2R / PLA2R1 Rabbit anti-Mouse Polyclonal (aa1418-1487) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
PLA2R / PLA2R1 Antibody - Western blot of PLA2R / PLA2R1 antibody.
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PLA2R / PLA2R1 Rabbit anti-Mouse Polyclonal (aa1418-1487) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
PLA2R / PLA2R1 Antibody - Western blot of PLA2R / PLA2R1 antibody.
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PLA2R / PLA2R1 Rabbit anti-Mouse Polyclonal (aa1418-1487) (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
PLA2R / PLA2R1 Antibody - Western blot of PLA2R / PLA2R1 antibody.
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PLA2R / PLA2R1 Rabbit anti-Mouse Polyclonal (aa1418-1487) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
PLA2R / PLA2R1 Antibody - Western blot of PLA2R / PLA2R1 antibody.
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PLA2R / PLA2R1 Rabbit anti-Mouse Polyclonal (aa1418-1487) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
PLA2R / PLA2R1 Antibody - Western blot of PLA2R / PLA2R1 antibody.
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PLA2R / PLA2R1 Rabbit anti-Mouse Polyclonal (aa1418-1487) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
PLA2R / PLA2R1 Antibody
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PLA2R / PLA2R1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
PLA2R / PLA2R1 Antibody - Western blot All Lanes: PLA2R1 antibody IgG at 0.78ug/ml+ Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 169,153 kDa Observed band size: 169 kDa
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PLA2R / PLA2R1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µl/$294; 100 µl/$360
PLA2R / PLA2R1 Antibody - Immunohistochemistry of paraffin-embedded rat liver using PLA2R1 antibodyat dilution of 1:100 (40x lens).
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PLA2R / PLA2R1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
PLA2R / PLA2R1 Antibody - Immunohistochemistry of paraffin-embedded Rat liver using PLA2R1 Polyclonal Antibody at dilution of 1:100 (40x lens).
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PLA2R / PLA2R1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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PLA2R / PLA2R1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
200 µl/$468
PLA2R / PLA2R1 Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue using PLA2R1 Antibody at dilution of 1:100
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PLA2R / PLA2R1 Rabbit anti-Human Polyclonal (aa395-530) Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
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PLA2R / PLA2R1 Rabbit anti-Human Polyclonal (aa395-530) (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
PLA2R / PLA2R1 Rabbit anti-Human Polyclonal (aa395-530) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
PLA2R / PLA2R1 Rabbit anti-Human Polyclonal (aa395-530) (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
PLA2R / PLA2R1 Antibody - Western blot of recombinant PLA2R / PLA2R1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PLA2R / PLA2R1 Rabbit anti-Human Polyclonal (aa385-643) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
PLA2R / PLA2R1 Antibody - Western blot of recombinant PLA2R / PLA2R1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PLA2R / PLA2R1 Rabbit anti-Human Polyclonal (aa385-643) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593
PLA2R / PLA2R1 Antibody - Western blot of recombinant PLA2R / PLA2R1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
PLA2R / PLA2R1 Rabbit anti-Human Polyclonal (aa385-643) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
PLA2R / PLA2R1 Antibody - Western blot of recombinant PLA2R / PLA2R1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
PLA2R / PLA2R1 Rabbit anti-Human Polyclonal (aa385-643) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
PLA2R / PLA2R1 Antibody - Western blot of recombinant PLA2R / PLA2R1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
PLA2R / PLA2R1 Rabbit anti-Human Polyclonal (aa385-643) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008
PLA2R / PLA2R1 Antibody - Western blot of recombinant PLA2R / PLA2R1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
PLA2R / PLA2R1 Rabbit anti-Human Polyclonal (aa385-643) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).