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PKMYT1

protein kinase, membrane associated tyrosine/threonine 1

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Gene Name: protein kinase, membrane associated tyrosine/threonine 1
Family/Subfamily: Protein Kinase , wee1/mik1
Synonyms: PKMYT1, Myt1 kinase
Target Sequences: NM_004203 NP_004194.3 Q99640

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
PKMYT1 (4)
No (4)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
PKMYT1 Protein - Purified recombinant protein PKMYT1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
54.3 kDa
20 µg/$1,107
PKMYT1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PKMYT1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
54.3 kDa
20 µg/$215
PKMYT1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
54.3 kDa
100 µg/$710
Viewing 1-4 of 4 product results


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Products: Proteins


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).