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Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Gene Name: | protein kinase, membrane associated tyrosine/threonine 1 |
Family/Subfamily: | Protein Kinase , wee1/mik1 |
Synonyms: | PKMYT1, Myt1 kinase |
Target Sequences: | NM_004203 NP_004194.3 Q99640 |
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