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PKD3 / PRKD3 belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking.
Gene Name: | protein kinase D3 |
Family/Subfamily: | Protein Kinase , PKD |
Synonyms: | PRKD3, EPK2, PKC-NU, Pkcn, Protein kinase C, nu, Protein kinase EPK2, PRKCN, Protein kinase C nu, Protein kinase C nu type, NPKC-NU, Pkcnu, PKD3, Protein kinase D3 |
Target Sequences: | NM_005813 NP_005804.1 O94806 |
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