PKD2 / Polycystin 2

polycystic kidney disease 2 (autosomal dominant)

Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.

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Products

ELISA Kits (7)

Type

Competitive EIA (1)

Custom (2)

Sandwich (4)

Target

PKD2 / Polycystin 2 (7)

Reactivity

Human (3)

Mouse (2)

Rat (1)

Format

12 x 8-Well Microstrips (1)

96-Well Strip Plate (6)

Publications

No (7)

Sample Type

Plasma (5)

Serum (5)

Tissue Homogenates (1)

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Human PKD2 / Polycystin 2 (Sandwich ELISA) ELISA Kit - LS-F33557

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human PKD2 / Polycystin 2 (Competitive EIA) ELISA Kit - LS-F13398

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse PKD2 / Polycystin 2 (Sandwich ELISA) ELISA Kit - LS-F38396

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Rat PKD2 / Polycystin 2 (Sandwich ELISA) ELISA Kit - LS-F38686

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human PKD2 / Polycystin 2 (Sandwich ELISA) ELISA Kit - LS-F37923

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Mouse PKD2 / Polycystin 2 (Custom ELISA) ELISA Kit - LS-F17577

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Bovine PKD2 / Polycystin 2 (Custom ELISA) ELISA Kit - LS-F17578

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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