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PKD1L2 is a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, where some individuals contain a non-functional allele. Alternative splicing results in multiple transcript variants.
Gene Name: | polycystic kidney disease 1-like 2 |
Synonyms: | PKD1L2, PC1-like 2 protein, KIAA1879, PC1L2, Polycystin-1L2 |
Target Sequences: | NP_443124.3 Q7Z442 |
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