PIM3 / PIM-3

pim-3 oncogene

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

PIM3 / PIM-3 (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human PIM3 / PIM-3 Protein (Recombinant GST, N-terminus) (aa242-326) - LS-G63963

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PIM3 / PIM-3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69997

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.7 kDa

Price:

20 µg/$1,107

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Human PIM3 / PIM-3 Protein (Recombinant His-T7) (aa1-326) - LS-G26205

Source:

E. coli

Tag:

His-T7

Molecular Weight:

39.6 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human PIM3 / PIM-3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86027

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.7 kDa

Price:

20 µg/$150

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PIM3 / PIM-3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122725

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.7 kDa

Price:

100 µg/$494

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