PIM1 / Pim-1

pim-1 oncogene

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

PIM1 / Pim-1 (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (1)

His (3)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Mouse PIM1 / Pim-1 Protein (Recombinant His) (aa122-261) - LS-G14993

Source:

E. coli

Tag:

His

Molecular Weight:

17.4 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human PIM1 / Pim-1 Protein (Recombinant His) - LS-G2214

Source:

E. coli

Tag:

His

Price:

50 µg/$373; 250 µg/$769; 10 µg/$276; 20 µg/$329; 100 µg/$479; 500 µg/$1,243

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Human PIM1 / Pim-1 Protein (Recombinant His-GST) (aa129-268) - LS-G14989

Source:

E. coli

Tag:

His-GST

Molecular Weight:

47.8 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Rat PIM1 / Pim-1 Protein (Recombinant His) (aa38-177) - LS-G14995

Source:

E. coli

Tag:

His

Molecular Weight:

17.4 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human PIM1 / Pim-1 Protein (Recombinant GST) (Full Length) - LS-G29741

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

60.28 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PIM1 / Pim-1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66589

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.5 kDa

Price:

20 µg/$1,107

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Human PIM1 / Pim-1 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G59608

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PIM1 / Pim-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117838

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.5 kDa

Price:

100 µg/$494

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Human PIM1 / Pim-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78056

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.5 kDa

Price:

20 µg/$150

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