PILRA

paired immunoglobin-like type 2 receptor alpha

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

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Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

PILRA (6)

Publications

No (6)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (4)

Species

Human (3)

Mouse (1)

Source

293T Cells (2)

HEK 293 Cells (2)

Human Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human PILRA Protein (Recombinant GST) (Full Length) - LS-G33497

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

50.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse PILRA Protein (Recombinant His) (Met1-Val197) - LS-G98231

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.2 kDa

Price:

100 µg/$721

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Human PILRA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89852

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.91 kDa

Price:

20 µg/$150

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Human PILRA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89853

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.8 kDa

Price:

20 µg/$150

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PILRA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114204

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.91 kDa

Price:

100 µg/$494

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PILRA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104735

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.8 kDa

Price:

100 µg/$494

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