PIKFYVE / PIP5K

Phosphoinositide Kinase, FYVE Finger Containing

Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Products

Antibodies (41)

Proteins (8)

ELISA Kits (1)

Type

Cell-Based (1)

Over-Expression Lysate (2)

Primary (41)

Recombinant (6)

Target

PIKFYVE / PIP5K (50)

Reactivity

Human (34)

Mouse (23)

Rat (6)

Application

IHC (21)

IHC-P (6)

WB (33)

ELISA (18)

IF (8)

Peptide-ELISA (5)

RNAi (1)

Host

rabbit (32)

mouse (9)

Product Group

IHCPlus (1)

Isotype

IgG (22)

IgG1 (6)

IgG2a (2)

IgG2a,k (1)

Clonality

monoclonal mc (9)

polyclonal pc (32)

Clone

6C7 (1)

OTI1A5 (2)

OTI1D2 (2)

OTI1D3 (2)

OTI2F11 (2)

Format

96-Well Microplate (1)

APC (1)

APC Conjugated (2)

Azide-free (1)

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Carrier-free (4)

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FITC Conjugated (2)

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PE Conjugated (2)

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Epitope

aa1680-1931 (8)

aa1531-1561 (7)

pSer307 (2)

250-330 aa (1)

40-120 aa, N-terminal (1)

Ab-307 (1)

C-Terminus (1)

aa1819-2098 (1)

aa273-322 (1)

aa46-95 (1)

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Publications

No (49)

Yes (1)

Sample Type

Adherent Cell Cultures (1)

Tag

GST (2)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (4)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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PIKFYVE / PIP5K Antibody LS-C334877

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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PIKFYVE / PIP5K Antibody (C-Terminus) LS-C209414

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$567

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IHC-plus™ PIKFYVE / PIP5K Antibody (40-120 aa, N-terminal) LS-B14219

(4.0) Rating

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (40-120 aa, N-terminal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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PIKFYVE / PIP5K Antibody (aa71-120) LS-C119339

(4.0) Rating

(1) Publication(s)

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (aa71-120) Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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PIKFYVE / PIP5K Antibody (clone 6C7) LS-C133847

Antibody:

PIKFYVE / PIP5K Mouse anti-Human Monoclonal (6C7) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, RNAi, WB

Format:

Unconjugated

Price:

100 µg/$423

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PIKFYVE / PIP5K Antibody (phospho-Ser307) LS-C199443

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (pSer307) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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PIKFYVE / PIP5K Antibody LS-C401349

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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PIKFYVE / PIP5K Antibody LS-C404629

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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PIKFYVE / PIP5K Antibody (aa1680-1931) LS-C295894

Antibody:

PIKFYVE / PIP5K Rabbit anti-Mouse Polyclonal (aa1680-1931) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

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Human PIKFYVE / PIP5K Protein (Recombinant GST) (Full Length) - LS-G36954

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

76.6 kDa

Price:

10 µg/$479; 25 µg/$670

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PIKFYVE / PIP5K Antibody (250-330 aa) LS-C381748

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (250-330 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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PIKFYVE / PIP5K Antibody (phospho-Ser307) LS-C823238

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (pSer307) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

100 µg/$357

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PIKFYVE / PIP5K Antibody (clone OTI1D2) LS-C795427

Antibody:

PIKFYVE / PIP5K Mouse anti-Human Monoclonal (OTI1D2) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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PIKFYVE / PIP5K Antibody (clone OTI1D2, Carrier-free) LS-C792450

Antibody:

PIKFYVE / PIP5K Mouse anti-Human Monoclonal (Carrier-free) (OTI1D2) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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PIKFYVE / PIP5K Antibody (aa1531-1561) LS-C328250

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (aa1531-1561) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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PIKFYVE / PIP5K Antibody (aa1531-1561, Biotin) LS-C245356

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (aa1531-1561) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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PIKFYVE / PIP5K Antibody (aa1531-1561, FITC) LS-C245357

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (aa1531-1561) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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PIKFYVE / PIP5K Antibody (aa1531-1561, APC) LS-C245355

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (aa1531-1561) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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PIKFYVE / PIP5K Antibody (aa1531-1561, PE) LS-C245360

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (aa1531-1561) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

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PIKFYVE / PIP5K Antibody (aa1531-1561, Azide-free, HRP) LS-C247766

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (aa1531-1561) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

PIKFYVE / PIP5K Antibody LS-C823314

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PIKFYVE / PIP5K Antibody (aa1819-2098) LS-C380358

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (aa1819-2098) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

PIKFYVE / PIP5K Antibody (aa1531-1561) LS-C99050

Antibody:

PIKFYVE / PIP5K Rabbit anti-Human Polyclonal (aa1531-1561) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PIKFYVE / PIP5K Antibody (clone OTI1A5) LS-C795428

Antibody:

PIKFYVE / PIP5K Mouse anti-Human Monoclonal (OTI1A5) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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PIKFYVE / PIP5K Antibody (clone OTI1A5, Carrier-free) LS-C799694

Antibody:

PIKFYVE / PIP5K Mouse anti-Human Monoclonal (Carrier-free) (OTI1A5) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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