PIK3CA / PI3K Alpha

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS.

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Products

ELISA Kits (6)

Type

Custom (1)

Sandwich (5)

Target

PIK3CA / PI3K Alpha (6)

Reactivity

Human (2)

Mouse (3)

Format

96-Well Strip Plate (6)

Publications

No (6)

Sample Type

Plasma (5)

Serum (5)

Tissue Homogenates (3)

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Human PIK3CA / PI3K Alpha (Sandwich ELISA) ELISA Kit - LS-F12338

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human PIK3CA / PI3K Alpha (Sandwich ELISA) ELISA Kit - LS-F33264

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse PIK3CA / PI3K Alpha (Sandwich ELISA) ELISA Kit - LS-F12339

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse PIK3CA / PI3K Alpha (Sandwich ELISA) ELISA Kit - LS-F33265

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Bovine PIK3CA / PI3K Alpha (Custom ELISA) ELISA Kit - LS-F17250

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Mouse PIK3CA / PI3K Alpha (Sandwich ELISA) ELISA Kit - LS-F53323

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

23.5 - 1500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$1,002

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