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PIK3C2B belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.
Gene Name: | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta |
Family/Subfamily: | Non-Protein Kinase , not assigned-Non-Protein Kinase |
Synonyms: | PIK3C2B, C2-PI3K, PI3K-C2-beta, PI3K-C2beta, PTDINS-3-kinase C2 beta, Phosphoinositide 3-kinase |
Target Sequences: | NM_002646 NP_002637.3 O00750 |
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