PIK3C2A

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

PIK3C2A (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human PIK3C2A Protein (Recombinant GST, N-terminus) (aa1577-1686) - LS-G59602

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PIK3C2A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89140

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

190.5 kDa

Price:

20 µg/$215

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PIK3C2A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99824

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

190.5 kDa

Price:

100 µg/$710

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Mouse PIK3C2A Protein (Recombinant His-GST) (aa349-611) - LS-G23999

Source:

E. coli

Tag:

His-GST

Molecular Weight:

61.9 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Human PIK3C2A Protein (Recombinant His-T7) (aa172-403) - LS-G12080

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.7 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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