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The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors.
Gene Name: | phosphatidylinositol glycan anchor biosynthesis, class Z |
Synonyms: | PIGZ, GPI-MT-IV, HSMP3, GPI mannosyltransferase 4, GPI mannosyltransferase IV, PIG-Z, SMP3, SMP3 homolog, SMP3 mannosyltransferase |
Target Sequences: | NM_025163 NP_079439.2 Q86VD9 |
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