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PIGP is an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene Name: | phosphatidylinositol glycan anchor biosynthesis, class P |
Synonyms: | PIGP, DCRC-S, DCRC, DSCR5, DSCRC, DSRC, PIG-P |
Target Sequences: | AB035742 BAA95633.1 P57054 |
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