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PIG8 / EI24 is a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8.
Gene Name: | etoposide induced 2.4 |
Synonyms: | EI24, EPG4, TP53I8, PIG8, p53-induced gene 8 protein |
Target Sequences: | NM_004879 NP_004870.3 O14681 |
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