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Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
Gene Name: | protein inhibitor of activated STAT, 3 |
Synonyms: | PIAS3, E3 SUMO-protein ligase PIAS3, ZMIZ5 |
Target Sequences: | NM_006099 NP_006090.2 Q9Y6X2 |
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