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PIAS2 / PIASX
protein inhibitor of activated STAT, 2
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
| Gene Name: | protein inhibitor of activated STAT, 2 |
| Synonyms: | PIAS2, ARIP3, DAB2-interacting protein, DIP, MIZ, MIZ1, PIAS-NY protein, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, E3 SUMO-protein ligase PIAS2 |
| Target Sequences: | NM_004671 NP_004662.2 O75928 |
Publications (2)
1
Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response. Conn KL, Wasson P, McFarlane S, Tong L, Brown JR, Grant KG, Domingues P, Boutell C. Journal of virology. 2016 90:4807-26. (ICC, WB; Human)
[Full Text Article]
[PubMed:26937035]
[PMC:PMC4836348]
Related Antibodies: LS-C108717.
2
SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1. Brown JR, Conn KL, Wasson P, Charman M, Tong L, Grant K, McFarlane S, Boutell C. Journal of virology. 2016 90:5939-52. (ICC, WB; Human)
[Full Text Article]
[PubMed:27099310]
[PMC:PMC4907222]
Related Antibodies: LS-C108717.
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Purified
(1)
PIAS2 / PIASX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
PIAS2 / PIASX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PIAS2 / PIASX Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa10-59) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
PIAS2 / PIASX Goat anti-Human Polyclonal (aa431-445) Antibody
Rabbit, Dog, Horse, Bat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa1-572) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa1-572) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa1-572) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa1-572) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PIAS2 / PIASX Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, WB
Unconjugated
100 µl/$424
PIAS2 / PIASX Rabbit anti-Mouse Polyclonal (C-Terminus) (HRP) Antibody
Mouse, Dog, Rat, Horse
IHC, WB
HRP Conjugated
100 µl/$469
PIAS2 / PIASX Rabbit anti-Mouse Polyclonal (C-Terminus) (Biotin) Antibody
Mouse, Dog, Rat, Horse
IHC, WB
Biotin Conjugated
100 µl/$469
PIAS2 / PIASX Rabbit anti-Mouse Polyclonal (C-Terminus) (FITC) Antibody
Mouse, Dog, Rat, Horse
IHC, WB
FITC Conjugated
100 µl/$469
PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PIAS2 / PIASX Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
PIAS2 / PIASX Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
PIAS2 / PIASX Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
PIAS2 / PIASX Mouse anti-Human Monoclonal (OTI5B4) Antibody
Human
WB
Unconjugated
100 µl/$434
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