PIAS1

protein inhibitor of activated STAT, 1

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

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Products

Antibodies (43)

ELISA Kits (11)

Proteins (4)

Type

Cell-Based (1)

Over-Expression Lysate (2)

Primary (43)

Recombinant (2)

Sandwich (9)

Sandwich CLIA (1)

Target

PIAS1 (58)

Reactivity

Human (45)

Mouse (19)

Rat (6)

Bat (7)

Bovine (6)

Chicken (4)

Chimpanzee (6)

Dog (3)

Gibbon (6)

Guinea pig (4)

Horse (7)

Monkey (8)

Pig (6)

Porcine (1)

Rabbit (5)

Xenopus (3)

Zebrafish (3)

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Application

IHC (25)

IHC-P (7)

WB (41)

Flo (1)

ELISA (17)

ICC (2)

IF (4)

IP (1)

Peptide-ELISA (2)

Host

rabbit (43)

Product Group

IHCPlus (1)

Isotype

IgG (22)

Clonality

polyclonal pc (43)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (2)

96-Well Strip Plate (8)

APC (1)

APC Conjugated (3)

Azide-free (2)

Biotin Conjugated (5)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (3)

Unconjugated (20)

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Epitope

aa409-645 (8)

aa607-637 (7)

aa100-130 (6)

N-Terminus (5)

C-Terminus (4)

10-90 aa, N-terminal (1)

Gly24 (1)

aa10-59 (1)

aa422-651 (1)

aa636-651 (1)

Publications

No (58)

Sample Type

Adherent Cell Cultures (1)

Plasma (5)

Serum (5)

Tissue Homogenates (1)

Tag

GST (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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PIAS1 Antibody LS-C408276

Antibody:

PIAS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

Flo, ICC, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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IHC-plus™ PIAS1 Antibody LS-B4649

(4.0) Rating

Antibody:

PIAS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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PIAS1 Antibody (aa636-651) LS-C313346

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa636-651) Antibody

Reactivity:

Rabbit, Mouse, Rat, Horse, Bat, Human, Monkey

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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PIAS1 Antibody (N-Terminus) LS-C110359

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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PIAS1 Antibody LS-C800569

Antibody:

PIAS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PIAS1 Antibody LS-C346096

Antibody:

PIAS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

PIAS1 Antibody (aa422-651) LS-C376330

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa422-651) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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PIAS1 Antibody (aa10-59) LS-C118608

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa10-59) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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PIAS1 Antibody (aa100-130) LS-C328231

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa100-130) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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PIAS1 Antibody (aa100-130, Biotin) LS-C220358

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa100-130) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

PIAS1 Antibody (aa100-130, FITC) LS-C220359

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa100-130) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

PIAS1 Antibody (aa100-130, APC) LS-C220356

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa100-130) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

PIAS1 Antibody (aa100-130, Azide-free, HRP) LS-C220360

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa100-130) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

PIAS1 Antibody (aa100-130, PE) LS-C220362

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa100-130) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

PIAS1 Antibody (aa607-637) LS-C328235

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa607-637) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

PIAS1 Antibody (aa607-637, Biotin) LS-C220352

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa607-637) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

PIAS1 Antibody (aa607-637, FITC) LS-C220353

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa607-637) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

PIAS1 Antibody (aa607-637, PE) LS-C220357

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa607-637) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

PIAS1 Antibody (aa607-637, Azide-free, HRP) LS-C220355

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa607-637) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

PIAS1 Antibody (aa607-637, APC) LS-C220350

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa607-637) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• HRP, Azide-free
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • HRP, Azide-free
  • APC

Select

PIAS1 Antibody (10-90 aa, N-terminal) LS-C385486

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

PIAS1 Antibody LS-C821732

Antibody:

PIAS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PIAS1 Antibody (aa607-637) LS-C98793

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (aa607-637) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PIAS1 Antibody (Gly24) LS-C176341

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (Gly24) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

PIAS1 Antibody (N-Terminus) LS-C413098

Antibody:

PIAS1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$266; 50 µl/$286; 100 µl/$321; 200 µl/$386

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