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Newark, CA 94560
United States
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PI4K2A / PI4KII
phosphatidylinositol 4-kinase type 2 alpha
Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.
| Gene Name: | phosphatidylinositol 4-kinase type 2 alpha |
| Family/Subfamily: | Non-Protein Kinase , not assigned-Non-Protein Kinase |
| Synonyms: | PI4K2A, DKFZP761G1923, RP11-548K23.6, PI4KII, PIK42A |
| Target Sequences: | NM_018425 NP_060895.1 Q9BTU6 |
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