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PI3 / Elafin

peptidase inhibitor 3, skin-derived

PI3 / Elafin is an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.

Gene Name: peptidase inhibitor 3, skin-derived
Synonyms: PI3, Cementoin, Elafin, Elastase-specific inhibitor, ESI, PI-3, Protease inhibitor WAP3, Trappin-2, Peptidase inhibitor 3, Protease inhibitor 3, SKALP, WAP3, WFDC14, Pre-elafin
Target Sequences: NM_002638 NP_002629.1 P19957

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Products
Proteins (12)
Over-Expression Lysate (2)
Recombinant (10)
PI3 / Elafin (12)
SDS-PAGE (1)
No (12)
6His, C-terminus (2)
6His, N-terminus (1)
GST (1)
His (3)
His,C-terminus (1)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (11)
293T Cells (1)
E. coli (3)
HEK 293 Cells (3)
Human Cells (1)
Insect Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Yeast (1)
Purified (3)
Low endotoxin level (4)
PI3 / Elafin Protein
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Yeast
6His, N-terminus
8.01 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
PI3 / Elafin Protein
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E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
PI3 / Elafin Protein
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E. coli
His
9.7 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
PI3 / Elafin Protein
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Insect Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
50 µg/$411; 250 µg/$1,236; 10 µg/$276
PI3 / Elafin Protein - 12.5% SDS-PAGE of human PI3 stained with Coomassie Blue
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Wheat Germ Extract
GST
38.61 kDa
10 µg/$479; 25 µg/$670
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
11kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
PI3 / Elafin Protein
Select
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human PI3 consists of 106 amino acids and has a predicted molecular mass of 11.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh PI3 is approximately 13-16 kDa.
50 µg/$403
PI3 / Elafin Protein - Purified recombinant protein PI3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
9.9 kDa
20 µg/$1,107
PI3 / Elafin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
12.27 kDa
100 µg/$494
PI3 / Elafin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
12.27 kDa
20 µg/$150
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
11.0 kDa
10 µg/$344; 50 µg/$584
Select
E. coli
His-SUMO
22.01 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Viewing 1-12 of 12 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).