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p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
Gene Name: | pleckstrin homology-like domain, family A, member 3 |
Synonyms: | PHLDA3, TIH1, TDAG51/Ipl homolog 1 |
Target Sequences: | NM_012396 NP_036528.1 Q9Y5J5 |
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