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PGC / Pepsin C

progastricsin (pepsinogen C)

PGC / Pepsin C is an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Gene Name: progastricsin (pepsinogen C)
Family/Subfamily: Protease , Aspartic A1
Synonyms: PGC, Gastricsin, Pepsinogen II, Pepsin C, Progastricsin, Pepsinogen group II, PGII, Preprogastricsin, Urinary pepsinogen 1, Pepsinogen C, Progastricsin (pepsinogen C)
Target Sequences: NM_002630 NP_002621.1 P20142

Publications (1)

1
Regeneration of severely damaged lungs using an interventional cross-circulation platform. Brandon A Guenthart, John D O'Neill, Jinho Kim, Dawn Queen, Scott Chicotka, Kenmond Fung, Michael Simpson, Rachel Donocoff, Michael Salna, Charles C Marboe, Katherine Cunningham, Susan P Halligan, Holly M Wobma, Ahmed E Hozain, Alexander Romanov, Gordana Vunjak-Novakovic, Matthew Bacchetta. Nature communications. 2019 May;10:1985. [Full Text Article] [PubMed:31064987] [PMC:PMC6504972]

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Products
ELISA Kits (24)
Competitive EIA (1)
Custom (3)
Sandwich (18)
Sandwich CLIA (2)
PGC / Pepsin C (24)
Human (6)
Mouse (6)
Rat (5)
Chicken (2)
Monkey (1)
Pig (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (2)
96-Well Microplate (3)
96-Well Strip Plate (19)
No (23)
Yes (1)
Cell Culture Supernatants (1)
Cell Lysates (1)
Plasma (17)
Serum (17)
Tissue Homogenates (7)
PGC / Pepsin C ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
PGC / Pepsin C ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
4.688 - 300 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PGC / Pepsin C ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.94 - 60 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
PGC / Pepsin C ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
PGC / Pepsin C ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
PGC / Pepsin C ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
PGC / Pepsin C ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
PGC / Pepsin C ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PGC / Pepsin C ELISA Kit
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Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PGC / Pepsin C ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$715
PGC / Pepsin C ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
10 - 250 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
PGC / Pepsin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
100 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
PGC / Pepsin C ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PGC / Pepsin C ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
PGC / Pepsin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PGC / Pepsin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
4.688 - 300 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PGC / Pepsin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PGC / Pepsin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
46.875 - 3000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PGC / Pepsin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PGC / Pepsin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
46.875 - 3000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PGC / Pepsin C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
PGC / Pepsin C ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$614
PGC / Pepsin C ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
0.938 - 60 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PGC / Pepsin C ELISA Kit
Select
Sandwich
96-Well Microplate
Human
40 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).