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PFKP

phosphofructokinase, platelet

The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.

Gene Name: phosphofructokinase, platelet
Synonyms: PFKP, 6-phosphofructokinase type C, 6-phosphofructokinase, type c, PFK-C, PFKF, Phosphofructokinase 1, Phosphofructokinase, platelet, Phosphohexokinase
Target Sequences: NM_002627 NP_002618.1 Q01813

Publications (2)

1
A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. Di A, Kawamura T, Gao XP, Tang H, Berdyshev E, Vogel SM, Zhao YY, Sharma T, Bachmaier K, Xu J, Malik AB. The Journal of biological chemistry. 2010 285:15848-57. [PubMed:20299461] [PMC:PMC2871452] Related Antibodies: LS-B8456.
2
ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Xue-Song Liu, Jenna E Haines, Elie K Mehanna, Matthew D Genet, Issam Ben-Sahra, John M Asara, Brendan D Manning, Zhi-Min Yuan. Genes & development. 2014 September;28:1917-28. [PubMed:25184678] [PMC:PMC4197949] Related Antibodies: LS-C173559.

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Products
Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
PFKP (8)
No (8)
GST (1)
GST, N-terminus (1)
His-T7 (3)
Myc-DDK (Flag) (3)
Human (5)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
PFKP Protein - 12.5% SDS-PAGE of human PFKP stained with Coomassie Blue
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Wheat Germ Extract
GST
111.98 kDa
10 µg/$479; 25 µg/$670
PFKP Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PFKP Protein - Purified recombinant protein PFKP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
85.4 kDa
20 µg/$1,107
PFKP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
85.4 kDa
100 µg/$494
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293T Cells
Myc-DDK (Flag)
85.4 kDa
20 µg/$150
PFKP Protein - Recombinant  Phosphofructokinase, Platelet By SDS-PAGE
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E. coli
His-T7
28.7 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
PFKP Protein - Recombinant Phosphofructokinase, Platelet By SDS-PAGE
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E. coli
His-T7
27.1 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
PFKP Protein - Recombinant Phosphofructokinase, Platelet By SDS-PAGE
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E. coli
His-T7
26.6 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).