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PFKP

phosphofructokinase, platelet

The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.

Gene Name: phosphofructokinase, platelet
Synonyms: PFKP, 6-phosphofructokinase type C, 6-phosphofructokinase, type c, PFK-C, PFKF, Phosphofructokinase 1, Phosphofructokinase, platelet, Phosphohexokinase
Target Sequences: NM_002627 NP_002618.1 Q01813

Publications (2)

1
A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. Di A, Kawamura T, Gao XP, Tang H, Berdyshev E, Vogel SM, Zhao YY, Sharma T, Bachmaier K, Xu J, Malik AB. The Journal of biological chemistry. 2010 285:15848-57. [PubMed:20299461] [PMC:PMC2871452] Related Antibodies: LS-B8456.
2
ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Xue-Song Liu, Jenna E Haines, Elie K Mehanna, Matthew D Genet, Issam Ben-Sahra, John M Asara, Brendan D Manning, Zhi-Min Yuan. Genes & development. 2014 September;28:1917-28. [PubMed:25184678] [PMC:PMC4197949] Related Antibodies: LS-C173559.

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ELISA Kits (11)
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12 x 8-Well Microstrips (1)
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Plasma (5)
Serum (5)
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PFKP ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
PFKP ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
PFKP ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$798
PFKP ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
PFKP ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
PFKP ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
PFKP ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PFKP ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PFKP ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PFKP ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PFKP ELISA Kit
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Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).