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PFKP
phosphofructokinase, platelet
The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.
| Gene Name: | phosphofructokinase, platelet |
| Synonyms: | PFKP, 6-phosphofructokinase type C, 6-phosphofructokinase, type c, PFK-C, PFKF, Phosphofructokinase 1, Phosphofructokinase, platelet, Phosphohexokinase |
| Target Sequences: | NM_002627 NP_002618.1 Q01813 |
Publications (2)
1
A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. Di A, Kawamura T, Gao XP, Tang H, Berdyshev E, Vogel SM, Zhao YY, Sharma T, Bachmaier K, Xu J, Malik AB. The Journal of biological chemistry. 2010 285:15848-57.
[PubMed:20299461]
[PMC:PMC2871452]
Related Antibodies: LS-B8456.
2
ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Xue-Song Liu, Jenna E Haines, Elie K Mehanna, Matthew D Genet, Issam Ben-Sahra, John M Asara, Brendan D Manning, Zhi-Min Yuan. Genes & development. 2014 September;28:1917-28.
[PubMed:25184678]
[PMC:PMC4197949]
Related Antibodies: LS-C173559.
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(91)
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(79)
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(25)
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(89)
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(1)
PFKP Mouse anti-Human Monoclonal (OTI1D6) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$450
PFKP Mouse anti-Human Monoclonal (Carrier-free) (OTI1D6) Antibody
Mouse, Rat, Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PFKP Rabbit anti-Human Polyclonal (aa754-784) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$440
PFKP Mouse anti-Human Monoclonal (OTI2E8) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PFKP Mouse anti-Human Monoclonal (Carrier-free) (OTI2E8) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PFKP Mouse anti-Human Monoclonal (OTI1F2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PFKP Mouse anti-Human Monoclonal (Carrier-free) (OTI1F2) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PFKP Mouse anti-Human Monoclonal (OTI3A12) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PFKP Mouse anti-Human Monoclonal (Carrier-free) (OTI3A12) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PFKP Mouse anti-Human Monoclonal (OTI1A11) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PFKP Mouse anti-Human Monoclonal (Carrier-free) (OTI1A11) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PFKP Mouse anti-Human Monoclonal (OTI3G8) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PFKP Mouse anti-Human Monoclonal (Carrier-free) (OTI3G8) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PFKP Mouse anti-Human Monoclonal (OTI3H8) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PFKP Mouse anti-Human Monoclonal (Carrier-free) (OTI3H8) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PFKP Mouse anti-Human Monoclonal (OTI2E10) Antibody
Human, Monkey
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PFKP Mouse anti-Human Monoclonal (Carrier-free) (OTI2E10) Antibody
Human, Monkey
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PFKP Mouse anti-Human Monoclonal (OTI5F7) Antibody
Human, Monkey
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PFKP Mouse anti-Human Monoclonal (Carrier-free) (OTI5F7) Antibody
Human, Monkey
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PFKP Mouse anti-Human Monoclonal (OTI2F2) Antibody
Human, Monkey
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PFKP Mouse anti-Human Monoclonal (Carrier-free) (OTI2F2) Antibody
Human, Monkey
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PFKP Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
PFKP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
PFKP Rabbit anti-Human Polyclonal (310-390 aa, Internal) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PFKP Rabbit anti-Human Polyclonal (aa350-400) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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